TRADOXY CAPSULE 

Doxycycline Hydrochloride BP 100 mg  
Read all of this leaflet carefully before you take this medicine.
• Keep this leaflet. You many need to read it again.
• If you have further questions, please ask your Pharmacist or Doctor.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

In this leaflet: 
1. What Tradoxy capsule  is and what it is used for
2. Precautions and warnings before you take Tradoxy capsule
3. How to take Tradoxy capsule 
4. Possible side effects.
5. Symptoms and treatment of over dosage
6. How to store Tradoxy capsule
7. Further information

1. WHAT TRADOXY CAPSULE IS AND WHAT IT IS USED FOR 
Tradoxy capsule contains a single active ingredient, Doxycycline Hydrochloride which belongs to a class of antibiotic drugs known as tetracyclines. Doxycycline is bacteriostatic. It binds reversibly to ribosomal units thereby inhibiting bacterial protein synthesis. Spectrum of activity includes many gram positive and negative organisms such as mycoplasma, rickettsia, chlamydia and spirochetes.

2. PRECAUTIONS AND WARNING BEFORE YOU TAKE TRADOXY CAPSULE  
Contraindication:
• Do not take Tradoxy capsule if you are allergic or hypersensitive to Doxycycline Hydrochloride, any of the ingredients of Tradoxy capsule or other tetracyclines.

Pregnancy and lactation:
• Do not take Tradoxy if you are pregnant or breast-feeding. Use during last half of pregnancy and in children under age 8 may cause permanent discoloration of teeth, enamel defects and bone growth retardation. 

Take special care with Tradoxy capsule if:
• You have impaired renal or hepatic function.   

Taking other Medicines:
• Please inform your Pharmacist or Doctor if you are taking or about to take any other medicine, including those obtained without a prescription.

Driving and using Machines 
Taking Tradoxy capsule may cause dizziness and impair your ability to perform tasks requiring alertness. Do not therefore operate machinery.

3. HOW TO TAKE TRADOXY CAPSULE 
• You should take the capsule exactly as your Doctor or Pharmacist directs you.
Adults and children weighing 45 kg and more: 100 mg

4. POSSIBLE SIDE EFFECTS
Like all medicines, Tradoxy capsule can cause side effects, although not everybody gets them. Side effects like intracranial hypertension, pericarditis, glossitis, dysphagia, epigastric distress, anorexia, nausea, vomiting, diarrhea, anogenital inflammation, enterocolitis, maculopapular and erythematous rashes, urticaria, increased pigmentation, hemolytic anemia and photosensitivity reactions have been rarely reported.

Possible interactions with food and drugs
Using Tradoxy together with antacids, laxatives containing magnesium, oral iron products, sodium bicarbonate, and zinc decrease oral absorption. Penicillin may antagonize bactericidal effects whilst carbamazepine and phenobarbital decrease antibiotic effect. There is decreased oral contraceptive effectiveness and increased risk of breakthrough bleeding when used together. Alcohol may decrease antibiotic effect so discourage use together.

5. SYMPTOMS AND TREATMENT OF OVER DOSAGE 
Signs and symptoms of overdose are usually limited to the GI tract and include nausea and vomiting. Clinicians are advised to treat with antacids or empty stomach by gastric lavage if ingestion occurred within the preceding 4 hours.

6. HOW TO STORE TRADOXY CAPSULE
Keep capsule out of reach or sight of children. Store them below 300c and in the original package. Check the expiry date on the label. Do not use product if the expiry date has passed.  

7. FURTHER INFORMATION
Each capsule contains Doxycycline Hydrochloride equivalent to 100 mg of Doxycycline. Other ingredients in the capsule are: Maize starch, sodium lauryl sulphate, gelatin, methyl paraben, silicon dioxide, talc and magnesium Stearate.  

Date of publication / review: Effective June, 2017, this publication is subject to review every two years and upon receipt of new product information.