PIROXICAM CAPSULE

Piroxicam B.P. 20mg 
Read all of this leaflet carefully before you take this medicine.

• Keep this leaflet. You many need to read it again.
• If you have further questions, please ask your Pharmacist or Doctor.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

In this leaflet: 

1. What Piroxicam capsule  is and what it is used for
2. Precautions and warning before you take Piroxicam capsule
3. How to take Piroxicam capsule
4. Possible side effects.
5. Symptoms and treatment of over dosage
6. How to store Piroxicam capsule
7. Further information

1. WHAT PIROXICAM CAPSULE IS AND WHAT IT IS USED FOR 
Piroxicam capsule contains a single active ingredient, Piroxicam, which belongs to a class of drugs known as NSAIDs (Non Steroidal Anti- Inflammatory Drugs). It is a non-narcotic analgesic and helps relief fever and pain due to swelling or inflammation of musculoskeletal origin. Piroxicam works in your body by inhibiting the synthesis of prostaglandins responsible for inflammation and pain.

2. PRECAUTIONS AND WARNING BEFORE YOU TAKE PIROXICAM CAPSULE  

Contraindication:
• Do not take Piroxicam capsule if you are allergic or hypersensitive to Piroxicam or any of the ingredients in the capsule.
• You have a history of bronchospasms or angioedema precipitated by aspirin or other NSAIDs. 

Pregnancy and lactation:
• Do not take Piroxicam if you are in your late pregnancy or breast-feeding.

Take special care with Piroxicam capsule if:
• You have impaired renal or hepatic function, peptic ulcer disease, GI disorders, cardiac disease, hypertension, or conditions predisposing to fluid retention.   

Stop taking Piroxicam capsule:
• At the first sign of anemia (presenting as tiredness, fast heart beat or paleness of skin/lips/nails) as well as other unusual symptoms such as skin rash, pruritus or significant edema or weight gain, and seek immediate medical attention.

Driving or using machinery:
• Avoid hazardous activities requiring alertness until CNS effects are known.

Taking other Medicines:
• Please inform your Pharmacist or Doctor if you are taking or about to take any other medicine, including those obtained without a prescription.

3. HOW TO TAKE PIROXICAM CAPSULE 
• You should take one capsule of daily or exactly as your Doctor or Pharmacist directs you. 

4. POSSIBLE SIDE EFFECTS
Like all medicines, Piroxicam capsule can cause side effects, although not everybody gets them. Side effects like dizziness, fluid retention, edema, angioedema, tinnitus, nausea, epigastria distress, dyspepsia, occult blood loss, peptic ulceration, hepatotoxicity, nephrotoxicity, blood dyscrasias, prolonged bleeding time, bronchospasms, rash, pruritus, and photosensitivity have been rarely reported.

Possible interactions with food and drugs 
Food delays absorption of Piroxicam while alcohol increases GI toxicity and decreases plasma levels. Piroxicam may decrease effectiveness of antihypertensives and diuretics; increase adverse GI effects with anti-inflammatory drugs, corticosteroids and salicylates; increased toxicity with nifedipine, phenytoin and verapamil; and potentiate hypoglycemic effects of insulin or oral antidiabetics. Coadministration with aspirin reduces Piroxicam levels by about 20 percent. 

Pharmacokinetics
Following single oral doses of 20 mg, Piroxicam is rapidly and fully absorbed, and eliminated with a mean plasma half life of about 45 hr. Mean peak concentrations are about 2micrigrams / ml after single 20 mg doses and about 6 mcg / ml at steady state with 20 mg daily. Steady state is achieved within 7 to 12 days with no appreciable accumulation thereafter.

5. SYMPTOMS AND TREATMENT OF OVER DOSAGE  
Signs and symptoms of overdose include GI discomfort, nausea, vomiting, drowsiness, oliguria, peripheral edema, auditory disturbances. 

Treat overdose by inducing emesis with ipecac syrup followed by activated charcoal. Use gastric lavage if patient is unconscious or ipecac fails. Respiratory support and correction of fluid and electrolyte imbalances may also apply.

6. HOW TO STORE PIROXICAM CAPSULE
Keep capsule out of reach or sight of children and store below 300C. Keep it in the original package. Check the expiry date on the label. Do not use product if the expiry date has passed.  

7. FURTHER INFORMATION
Each Capsule contains 20mg of Piroxicam USP. Other ingredients in the capsule are: Sodium lauryl sulphate, Gelatin, Methyl paraben, Maize starch, Silicon dioxide, Talc and Magnesium Stearate. 

Presentation: Each box contains ten (10) blisters of ten (10) capsules each.

Date of publication / review: Effective January, 2017, this publication is subject to review every two years and upon receipt of new product information.