TRIHEPTA TABLET

Cyproheptadine Hcl  B.P.  4mg  
Thiamine Mononitrate  B.P. 0.5mg
Nicotinamide   B.P.   2mg 
Pyridoxine Hcl   B.P 1 mg

Read all of this leaflet carefully before you take this medicine.
• Keep this leaflet. You may need to read it again.
• If you have further question, please ask your Pharmacist or your Doctor.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

In this leaflet:

1. What Trihepta tablet is and what it is used for:
2. Precautions and warning before you take Trihepta tablet
3. How to take Trihepta tablet
4. Possible side effects.
5. Symptoms and treatment of over dosage
6. How to store Trihepta tablet
7. Further information

1. WHAT TRIHEPTA TABLET IS AND WHAT IT IS USED FOR 
Trihepta tablet is a proprietary combination medicine containing four (4) active ingredients, namely, Cyproheptadine, Thiamine mononitrate, Nicotinamide and Pyridoxine Hcl. Cyproheptadine is an appetite stimulant drug. Thiamine, Nicotinamide and Pyridoxine are essential B-complex vitamins that enhance metabolic activities in the body. The actions of all four (4) agents in the body may help boost appetite.

2. PRECAUTIONS AND WARNING BEFORE YOU TAKE TRIHEPTA TABLET

Contraindication:
• Do not take Trihepta tablet if you are allergic or hypersensitive to the active drugs or any of the ingredients of Trihepta tablet.
• You have acute asthma, angle-closure glaucoma, stenosing peptic ulcer, symptomatic prostatic hyperplasia, bladder neck obstruction, and pyloroduodenal obstruction.
• You are taking monoamine oxidase (MAO) inhibitors
• You are a geriatric or debilitated patient

Pregnancy and lactation: 
• Pregnant and breast feeding mothers should not take Trihepta tablet 

Take special care with Trihepta tablet if:
• You have increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension or bronchial asthma   

Taking other Medicines:
• Please inform your Pharmacist or Doctor if you are taking or about to take any other medicine, including those obtained without a prescription.

Driving and using Machines 
• Trihepta may cause sedation or dizziness, hence avoid operating machinery or any activity that requires alertness when taking Trihepta tablet.

3. HOW TO TAKE TRIHEPTA TABLET
Trihepta tablet may be taken with food or milk to reduce potential GI distress.

• Adults should take one tablet with a glass of water 2-3 times daily.
• Children aged 12years and above should take one tablet once or twice daily.

4. POSSIBLE SIDE EFFECT
Like all medicines, Trihepta tablet can cause side effects, although not everybody gets them. Side effects like dizziness, sleepiness, insomnia, confusion, seizure, toxic psychosis, palpitation, hypotension, tachycardia, dry mouth, diarrhea, constipation, nausea, vomiting, urine retention, urinary frequency, hemolytic anaemia, blood dyscrasias, rash, urticaria, photosensitivity, anaphylactic shock have been reported.

Possible interactions with food and drugs
Food may delay the rate but not the extent of Cyproheptadine absorption. Trihepta tablet should not be used together with CNS depressant drugs and MAO inhibitors. Concurrent use of Trihepta and Thyrotropin releasing hormone would require close monitoring by your physician.

5. SYMPTOMS AND TREATMENT OF OVER DOSAGE 
Signs and symptoms of overdose may include either CNS depression (sedation, reduced mental alertness, apnoea, and CV collapse) or CNS stimulation (insomnia, hallucinations, tremors, or seizures). Anticholinergic symptoms such as dry mouth, flushed skin, fixed and dilated pupils, and GI symptoms are common, especially in children. Overdose should be treated by emesis with ipecac syrup followed by activated charcoal in conscious patient or gastric lavage if patient is unconscious or ipecac fails.

6. HOW TO STORE TRIHEPTA TABLET
Keep tablet out of reach or sight of children. Store product below 300c in the original package. Check the expiry date on the label and do not use product if expired.  

7. FURTHER INFORMATION
In addition to Cyproheptadine, Thiamine mononitrate, Nicotinamide and Pyridoxine, the other ingredients in Trihepta tablet are: Povidone, Mannitol, Dicalcium phosphate, Sodium methylparaben, Maize starch, Silicon dioxide, Talc and Magnesium Stearate.  

Presentation: Each box contains two blister packs of ten tablets each.

Date of publication / review: Effective January, 2014, this publication is subject to review every two years and upon receipt of new product information.